- 24 North Hotel Key West
- Alexander Palms Court
- Almond Tree Inn
- Ambrosia Key West
- An Island Oasis
- Andrews Inn & Garden Cottages
- Artist House Key West
- Best Western Hibiscus Motel
- Blue Marlin Motel
- Caribbean House
- Casa 325 Guesthouse
- Casa Marina Key West, Curio Collection by Hilton
- Coco Plum Inn
- Courtney's Place Historic Cottages & Inns
- Courtyard by Marriott Key West Waterfront
- Curry House
- DoubleTree Resort by Hilton Grand Key - Key West
- Douglas House
- Duval House
- Duval Inn
- Eden House
- El Patio Motel
- Fairfield Inn & Suites by Marriott Key West
- Fairfield Inn & Suites by Marriott Key West at The Keys Collection
- Galleon Resort and Marina
- H2O Suites- Adults Only
- Heron House - Adult Only
- Heron House Court - Adult Only
- Hilton Garden Inn Key West / The Keys Collection
- Hyatt Centric Key West Resort And Spa
- Hyatt Residence Club Key West, Beach House
- Ibis Bay Resort
- Knowles House B&B
- L'Habitation Guest House
- La Concha Key West
- La Pensione Inn - Adult Exclusive
- La Te Da Hotel - Adults Only
- Marreros Guest Mansion - Adult Only
- NYAH Key West - Adult Exclusive
- New Orleans House - Gay Male Adult Guesthouse
- Ocean Key Resort & Spa, a Noble House Resort
- Oceans Edge Key West Resort, Hotel & Marina
- Old Town Manor
- Opal Key Resort & Marina
- Orchid Key Inn
- Paradise Inn Key West - Adults Only
- Parrot Key Hotel & Villas
- Pegasus International Hotel
- Pier House Resort & Spa
- Santa Maria Suites
- Seascape Tropical Inn
- Seashell Motel and International Hostel
- Silver Palms Inn
- Simonton Court Historic Inn & Cottages
- Smallest Bar Inn
- Southernmost Beach Resort
- Southernmost Point Guest House
- Southwinds Motel
- Suite Dreams Inn by the Beach
- Sunrise Suites Resort
- Sunset Key Cottages
- The Cabana Inn Key West - Adults Only
- The Capitana Key West
- The Casablanca Hotel
- The Conch House Heritage Inn
- The Garden House
- The Gardens Hotel
- The Gates Hotel Key West
- The Grand Guesthouse
- The Guesthouses at Southernmost Beach Resort - Adults only
- The Inn On Fleming
- The Laureate Key West
- The Mansion on the Sea - Southernmost House in the USA
- The Marker Key West Harbor Resort
- The Marquesa Hotel
- The Palms Hotel
- The Perry Hotel & Marina Key West
- The Porch on Frances Inn - Adults Exclusive
- The Reach Key West, Curio Collection by Hilton
- The Saint Hotel Key West Autograph Collection
- The Southernmost Inn-Adults Only
- Truman Hotel
- Weatherstation Inn
- Westwinds Inn
- Wicker Guesthouse